exploit knowledge of the fundamental principles of molecularbiology to analyze contributions of DNA and proteins to human physiologyand behavior
identify, select, and query the appropriate database to best answerthe bioinformatics question at hand, and effectively and accuratelyinterpret the outcome
use information gained from the application of bioinformatics toappreciate its impact on proteomics, epidemiology, and evolutionarybiology
recognize current and emerging technical challenges and areas ofinnovation inherent in the field of bioinformatics to target careeropportunities and development
For the final project, you will use the gene you identified in thegene annotation project and the protein used in protein annotationproject to:
Identify the diseases implicated by your gene: genomic features at the gene level. i.e SNPs
Identify the diseases implicated at protein level: mutations atprotein and structural levels: could include variations in amino acid,motifs, functions etc.
Select one disease either at the gene or protein level and provide more detailed discussion on:
Briefly explain the disease mechanism as it relates to the gene/protein
The bioinformatics approaches used to identify the specific genomic features implicated
Identify and discuss the bioinformatics and data analysis tools to identify the implicated genomic features the disease.
Discuss the drug targets identified if any implicated pathway
General requirements:
Screenshots must be provided for the tools used.
Minimum number of pages is 3 and maximum is 6 pages (750 1500 words)
Must include references
It must be written in a research paper format including an abstract and title.
Content
Excellent
Very Good
Good
Fair
Poor
Points
4
3
2
1
0
General Requirements
All the general requirements are met
Most of the general requirements are met
Some of the general requirements are met
A few general requirements are met
no answer
Abstract
Very well written abstract indicating what the paper is about
Good abstract
Fairly-written abstract
Very vague abstract not indicating what the paper is about
no answer
Disease identification
Identifies diseases and the genomic features at both gene and protein levels
Identifies at the diseases and implicated genomic features only at either protein or gene level
Identifies diseases at both protein and gene level but not the genomic features
Identifies the diseases only at either gene or protein levels and no genomic features
no answer
Disease mechanism
Very well written description of the disease mechanism
Good description of the disease mechanism
Fair description of the disease mechanism
Vague description of the disease mechanism
no answer
Bioinformatics approaches
Clearly describes the bioinformatics approaches
Good description of the bioinformatics approaches
Fair description of the bioinformatics approaches
Vague description of the bioinformatics approaches
No answer
Bioinformatics and data analysis tools
Correct and good discussion identification of bioinformatics & data analysis tool
Correct tools are identified and fairly -discussed
Correct tools are identified but no discussion
Identified tools cannot be used for identifying implicated genomic features in the selected disease
No answer
Drug targets & pathways
Identifies the correct drug targets and the implicated pathways
Identifies the drug targets but not the pathways
Identifies the pathway but no drugs
Wrong identifications of pathways and drug targets
No answer
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