Final project (10 points): Based on the topics we cover, students must select a topic to write a 1200 words paper

Introductory Paragraph: In this paragraph, your goal should be to introduce your research subject to the reviewers and quickly capture their attention. This paragraph should describe the significant gap in knowledge that directly relates to the critical need the funding entity deals with. It is critical to know your funding entity’s mission statement and ensure the critical need you are trying to fill fits well within its mission. It should include the following information: . First Sentence/Hook: Explain WHAT your research topic is and WHY it is critical that you conduct the research. . What is Known: State what is currently known in the specific field (3-5 sentences). Provide the reader with only the necessary details to understand why you are proposing the work. Remember to be concise and focused on only the key points. . Gap in Knowledge: Clearly state the gap in knowledge that needs to be addressed. Convey that your research will fill this gap using the funding that you are requesting. You can emphasize the most important words or phrases in your Specific Aims page by using italics or underline, but do so moderately. Overuse of italics or underlining can be distracting. . The Critical Need: The critical need is the knowledge (hypothesis-driven), technique, new compound, or treatment that you propose to develop. The critical need is the reason your proposal should be funded. Emphasize the significance of the problem you are trying to address. Additionally, it should be clear in this paragraph that your research proposes the next logical step to advance the field. II. The Second Paragraph In this paragraph, your goal should be to introduce the solution that fills the gap in knowledge. It is critical to convince your reviewers that you (and your colleagues) have the solution to address the current knowledge gap and the expertise to accomplish this solution. Keep your wording simple, relevant, and to the point. You will want to address the following points: . What do you want to do? . Why are you doing it? . How do you want to do it? There is some flexibility in this paragraph, depending upon how your proposal is structured and what your goals are. For example, your research may be strictly hypothesis-driven and seek to test several elements of one general hypothesis. In other cases, you may be seeking to develop a critical tool or technique in the proposal. Based on these variations, this paragraph will shape up differently. However, it should include the following components: . Long-Term Goal: This is your overarching research goal. Align your long-term goals with the mission of your funding entity. Keep your wording general in this sentence.”you are stating your long-term plans, and the reviewers understand that the specifics may be subject to change. . Hypothesis and Proposal Objectives: Your proposal should contain both of these components, depending on the long-term goal. State your central hypothesis clearly, specifically, and with simple language. Describe how your project addresses the critical need, and clearly state the proposed solution. In general, avoid vague hypotheses because it will be unclear to the reviewers what you expect to determine with the proposed research. . Rationale: Explain how you arrived at your central hypothesis (for example, using past studies and published literature). Briefly, state what your project’s completion would make possible (e.g., new therapeutics), and tie it to the funding entity’s mission. . Qualifications: Briefly state why your experimental design and your team are the best to accomplish the research goals. You can mention factors such as your preliminary data, personnel qualifications, laboratory equipment, etc., but it is important to keep it concise.